منابع مشابه
Deep Learning Mutation Prediction Enables Early Stage Lung Cancer Detection in Liquid Biopsy
Somatic mutation calling at ultra low allele frequencies is an unmet challenge that is intractable with current state-of-the-art mutation calling methods. The ability to detect cancer associated mutations in ultra low allele frequency is a fundamental requirement for cancer early detection, monitoring, and therapy nomination using liquid biopsy methods (cell-free DNA). Here we defined a spatial...
متن کاملThe liquid biopsy in lung cancer
The incidence of lung cancer has significantly increased over the last century, largely due to smoking, and remains the most common cause of cancer deaths worldwide. This is often due to lung cancer first presenting at late stages and a lack of curative therapeutic options at these later stages. Delayed diagnoses, inadequate tumor sampling, and lung cancer misdiagnoses are also not uncommon due...
متن کاملOpen lung biopsy in early-stage acute respiratory distress syndrome
INTRODUCTION Acute respiratory distress syndrome (ARDS) has heterogeneous etiologies, rapid progressive change and a high mortality rate. To improve the outcome of ARDS, accurate diagnosis is essential to the application of effective early treatment. The present study investigated the clinical effects and safety of open lung biopsy (OLB) in patients with early-stage ARDS of suspected non-infect...
متن کاملLiquid Biopsy in Non-Small Cell Lung Cancer
Liquid biopsy analyses are already incorporated in the routine clinical practice in many hospitals and oncology departments worldwide, improving the selection of treatments and monitoring of lung cancer patients. Although they have not yet reached its full potential, liquid biopsy-based tests will soon be as widespread as "standard" biopsies and imaging techniques, offering invaluable diagnosti...
متن کاملLiquid biopsy genotyping in lung cancer: ready for clinical utility?
Liquid biopsy is a blood test that detects evidence of cancer cells or tumor DNA in the circulation. Despite complicated collection methods and the requirement for technique-dependent platforms, it has generated substantial interest due, in part, to its potential to detect driver oncogenes such as epidermal growth factor receptor (EGFR) mutants in lung cancer. This technology is advancing rapid...
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ژورنال
عنوان ژورنال: Translational Lung Cancer Research
سال: 2016
ISSN: 2218-6751,2226-4477
DOI: 10.21037/tlcr.2016.10.15